Creating Functional Molecules for Biology & Medicine

Acyl-protein thioesterase 1 (LYPLA1) activity promotes the growth of MDA-MB-468 triple-negative breast cancer cells.

Salsaa, M.; Tavasoli, M.; Zein, H.S.; Pani, S.; Kathayat, R.S.; Dickinson, B.C.; Fairn, G.D.

Submitted. BioRxiv

Mapping the diverse topologies of protein-protein interaction fitness landscapes.

Lu, S.S.; Styles, M.J.; Gao, C.F.; Nandy, A.; Basile, C.; Pixley, J.A.; Tao, S.; Dinner, A.R.; Vaikuntanathan, S.; Dickinson, B.C.

In prep. BioRxiv

PANCS-spec-binders: A system for rapidly discovering isoform- or epitope-specific binders.

Pixley, J.A.; Styles, M.J.; Aphicho, K.; Endres, M.; Gade, P.; Michalska, K.; Joachimiak, A.; Dickinson, B.C.

In revision, PNAS. BioRxiv

A rapid binder discovery workflow for engineering mini-protein degraders.

Yang, J.; Styles, M.J.; Aphicho, K.; Hajime, A.; Komatsu, S.; Pineda, E.; Matsuzaki, J.; Odunsi, K.; Tsuji, T.; Dickinson, B.C.

In Revision, JACS. ChemRxiv

Engineering a human protein-based translational activator for Dravet syndrome haploinsufficiency.

Sinnott, R.; Solanki, A.; Govind, A.P.; Green, W.N.; Dickinson, B.C.

Nucleic Acids Research, 54, gkag113 (2026).

Toward Universal Binder Discovery: Advances in Display, Computational Design and in vivo platforms.

Yang, J.; Pineda, E.; Dickinson, B.C.

Curr. Opin. Chem. Biol., 92, 102663 (2026).

Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling.

Ogorek, A.N.; Pani, S.; Mertick-Sykes, E.J.; Momirov, J.; Lao, Y.; Banales Mejia, F.; St Chan, R.; Huang, X.; Dickinson, B.C.*; Martell, J.D.*

ACS Cent. Sci., 12, 185-196 (2026). *co-corresponding authors

Mapping and Rewiring Biology via Proximity Induction.

Arkin, M.; Dickinson, B.C.; Winter, G.

Acc. Chem. Res., XXX, XXX-XXX (2026).

Discovery of macrocyclic peptide binders, covalent modifiers, and degraders of a structured RNA by mRNA display.

Yao, X.; Aphicho, K.; Pani, S.; Rupanya, A.; Lan, T.; Dickinson, B.C.

J. Am. Chem. Soc., 147, 34256-34270 (2025). ChemRxiv

PANCS-Binders: A rapid, high-throughput binder discovery platform.

Styles, M.J.; Pixley, J.A.; Wei, T.; Basile, C.; Lu, S.S.; Dickinson, B.C.

Nat. Methods, 22, 1720-1730 (2025). BioRxiv

N6-methyladenosine reader YTHDF3-mediated CEBPA translation maintains genomic stability and stem cell function to prevent liver injury.

Liang, Y.; Yu, W.; Sun, H.; Wang, D.; Wang, Z.; Shi, H.; Cao, Y.; Zhang, Z.; Liu, J.; Zou, Z.; Wei, J.; Wu, T.; Yu, D.; Qi, J.; Wu, J.; Dickinson, B.C.; Zhu, P.; Shen, B.; Sun, B.; He, C.; Zhong, X.

Sci. China Life Sci., 68, 2456-2471 (2025).

FoxO1-zDHHC4 axis increases CD36 S-acylation driving metabolic dysfunction in the type 2 diabetic heart.

Dennis, K.M.J.H.; Montes Aparicio, C.N.; Devereux, R.; Carter, R.; Zhang, J.A.; Castro-Guarda, M.; Gopal, K.; Nicol, T.; Azizi, S.-A.; Lan, T.; Purnama, U.; Carr, C.A.; Schianchi, F.; Luiken, J.J.F.P.; Aksentijevic, D.; Dunker, D.; Dickinson, B.C.; De Val, S. Ussher, J.R.; Fuller, W.; Heather, L.C.

Circ. Res., 136, 1545-1560 (2025).

Dynamic PRDX S-acylation modulates ROS stress and signaling.

Qiu, T.; Azizi, S.-A.; Pani, S.; Dickinson, B.C.

Cell Chem. Biol., 32, 511-519 (2025).

Introduction: Synthetic Biology.

Dickinson, B.C.

Chem. Rev., 125, 3005-3006 (2025).

Discovery of Thioether-Cyclized Macrocyclic Covalent Inhibitors by mRNA Display.

Lan, T.; Peng, C.; Yao, X.; Chan, R.S.T.; Wei, T.; Rupanya, A.; Radakovic, A.; Wang, S.; Chen, S.; Lovell, S.; Snyder, S.A.; Bogyo, M.; Dickinson, B.C.

J. Am. Chem. Soc., 146, 24053-24060 (2024).

Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release.

Liu, Z.; Li, S.; Wang, C.; Vidmar, K.; Bracey, S.; Li, L.; Willard, B.; Miyagi, M.; Lan, T.; Dickinson, B.C.; Osme, A.; Pizarro, T.T.; Xiao, T.S.

Proc. Natl. Acad. Sci., U.S.A., 121, e2400883121 (2024).

Development of Luminescent Biosensors for Calprotectin.

Lan, T.; Slezak, T.; Pu, J.; Zinkus-Boltz, J.; Adhikari, S.; Pekow, J.R.; Taneja, V.; Zuniga, J.; Gomez-Garcia, I.A.; Regino-Zamarripa, N.E.; Ahmed, M.; Khader, S.; Rubin, D.T.; Kossiakoff, A.A.; Dickinson, B.C.

ACS Chem. Biol., 19, 1250-1259 (2024).

Expanding RNA editing toolkit using an IDR-based strategy.

Di, M.; Lv, J.; Jing, Z.; Yang, Y.; Yan, K.; Wu, J.; Ge, J.; Rauch, S.; Dickinson, B.C.*; Chu, T.*

Mol. Ther. Nucleic Acids, 25, 102190 (2024). *co-corresponding authors

Biorthogonal masked acylating agents for proximity-dependent RNA labeling.

Pani, S.; Qiu, T.; Kentala, K.; Azizi, S.-A.; Dickinson, B.C.

Nat. Chem., 16, 717-726 (2024). ChemRxiv

AI is a viable alternative to high throughput screening: a 318-target study.

The Atomwise AIMS Program*.

Sci. Rep., 14, 7526 (2024). *Consortium

Engineered RNA-binding proteins: Studying and Controlling RNA Regulation.

Sinnott, R.; Cao, Y.; Dickinson, B.C.

Isr. J. Chem., e202300169 (2024).

Mechanisms and functions of protein S-acylation.

Mesquita, F.S.; Abrami, F.; Linder, M.E.; Bamji, S.X.; Dickinson, B.C.; van der Goot, G.

Nat. Rev. Mol. Cell Biol., 25, 488-509 (2024).

Bump-Hole ZDHHCs.

Lan, T. and Dickinson, B.C.

Nat. Chem. Biol., 20, 666-667 (2024).

Fear extinction is regulated by long noncoding RNA activity at the synapse.

Liau, W.S.; Zhao, Q.; Bademosi, A.; Gormal, R.S.; Gong, H.; Marshall, P.R.; Periyakaruppiah, A.; Madugalle, S.U.; Zajackowski, E.L.; Leighton, L.J.; Ren, H.; Musgrove, M.; Davies, J.; Rauch, S.; He, C.; Dickinson, B.C.; Li, X.; Wei, W.; Meunier, F.A.; Fernandez Moya, S.M.; Kiebler, M.; Srinivasan, B.; Banerjee, S.; Clark, M.; Spitale, R.C.; Bredy, T.W.

Nat. Commun., 14, 7616 (2023). bioRxiv

RNA-based translational activators for targeted gene upregulation.

Cao, Y.; Liu, H.; Lu, S.S.; Jones, K.A.; Govind, A.P.; Jeyifous, O.; Simmons, C.Q.; Tabatabaei, N.; Green, W.N.; Holder, J.L; Tahmasebi, S.; George, A.L.; Dickinson, B.C.

Nat. Commun., 14, 6827 (2023).

Regulation of ERK2 by dynamic S-acylation.

Azizi, S.-A.; Qiu, T.; Brookes, N.; Dickinson, B.C.

Cell Reports, 42, 113135 (2023). bioRxiv

Synapse-enriched m6A-modified Malat1 interacts with the novel m6A reader, DPYSL2, and is required for fear-extinction memory.

Madugalle, S.U.; Liau, W.-S.; Zhao, Q.; Li, X.; Gong, H.; Marshall, P.R.; Periyakaruppiah, A.; Zajaczkowski, E.L.; Leighton, L.J; Ren, H.; Musgrove, M.R.B.; Davies, J.; Rauch, S.; He, C.; Dickinson, B.C.; Fulopova, B.; Fletcher, L.N.; Williams, S.R.; Spitale, R.C.; Bredy, T.W.

J. Neurosci., 43, 7084-7100 (2023). bioRxiv

Nm-Mut-seq: A base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation.

Chen, L.; Zhang, L.-S.; Ye, C.; Zhou, H.; Liu, B.; Gao, B.; Deng, Z.; Zhao, C.; He, C.; Dickinson, B.C.

Cell Res., 33, 727-730 (2023).

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies.

Azad, T.; Rezaei, R.; Singaravelu, R.; Pelin, A.; Boulton, S.; Petryk, J.; Onsu, K.A.; Martin, N.T.; Hoskin, V.; Ghahremani, M.; Marotel, M.; Marius, R.; He, X.; Crupi, M.J.F.; Hoang, H.-D.; Nik-Akhtar, A.; Ahmadi, M.; Zamani, N.K.; Golshani, A.; Alain, T.; Greer, P.; Ardolino, M.; Dickinson, B.C.; Tai, L.-H.; Ilkow, C.S.; Bell, J.C.

Nat. Commun., 14, 3035 (2023).

Innate conformational dynamics drive binding specificity in anti-apoptotic proteins Mcl-1 and Bcl-2.

Wolf, E.; Pu, J.; Dickinson, B.C.; Wilson, D.J.

Biochemistry, 62, 1619-1630 (2023). bioRxiv

Engineering rapalog-inducible genetic switches based on Split-T7 polymerase to regulate oncolytic virus-driven production of tumour-localized IL-12 for anti-cancer immunotherapy.

Martin, N.T.; Crupi, M.J.F.; Taha, Z.; Poutou, J.; Whelan, J.; Vallati, S.; Petryk, J.; Marius, R.; Austin, B.; Azad, T.; Boulanger, M.; Burgess, T.; Sanders, I.; Victoor, C.; Dickinson, B.C.; Diallo, J.-S.; Ilkow, C.S.; Bell, J.C.

Pharmaceuticals, 16, 709 (2023).

Activity-dependent post-translational regulation of palmitoylating and de-palmitoylating enzymes in the hippocampus.

Abazari, D.; Wild, A.R.; Qiu, T.; Dickinson, B.C.; Bamji, S.X.

J. Cell Sci., 136, jcs260629 (2023). bioRxiv

Palmitoylation couples insulin hypersecretion with β-cell failure in diabetes.

Dong, G.; Adak, D.; Spyropoulos, G.; Zhang, Q.; Feng, C.; Lin, Y.; Speck, S.L.; Shyr, C.; Morikawa, S.; Kitamura, R.A.; Kathayat, R.S.; Dickinson, B.C.; Ng, X.W.; Piston, D.W.; Urano, F.; Remedi, M.S.; Wei, X.; Semenkovich, C.F.

Cell Metabolism, 35, 332-344 (2023).

Trypanosoma brucei Acyl-Protein Thioesterase-like (TbAPT-L) is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but has no Depalmitoylation Activity.

Brown, R.W.B.; Sharma, A.I.; Villanueva, N.R.; Li, X.; Onguka, O.; Zilbermintz, L.; Nguyen, H.; Falk, B.A.; Olson, C.L.; Taylor, J.M.; Epting, C.L.; Kathayat, R.S.; Amara, N.; Dickinson, B.C.; Bogyo, M.; Engman, D.M.

Pathogens, 11, 1245 (2022).

Charting the chemical space of acrylamide-based inhibitors of zDHHC20.

Azizi, S.-A.; Delalande, C.; Lan, T.; Qiu, T.; Dickinson, B.C.

ACS Med. Chem. Lett., 13, 1648-1654 (2022).

A high-throughput fluorescent turn-on assay for inhibitors of DHHC family proteins.

Qiu, T.; Azizi, S.-A.; Brookes, N.; Lan, T.; Dickinson, B.C.

ACS Chem. Biol., 17, 2018-2023 (2022).

Development of mild chemical catalysis conditions for m1a-to-m6A arrangement on RNA.

Liu, H.; Zeng, T.; He, C.; Rawal, V.; Zhou, H.; Dickinson, B.C.

ACS Chem. Biol., 17, 1334-1342 (2022).

Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration.

Lüebben, A.V.; Bender, D.; Becker, S.; Crowther, L.M.; Erwen, I.; Hofmann, K.; Söding, J.; Klemp, H.; Bellotti, C.; Stäuble, A.; Qiu, T.; Kathayat, R.S.; Dickinson, B.C.; Gärtner, J.; Sheldrick, G.M.; Krätzner, R.; Steinfeld, R.

Science Advances, 8, eabj8633 (2022).

CASowary: CRISPR-Cas13 guide RNA predictor for transcript depletion.

Krohannon, A.; Srivastava, M.; Rauch, S.; Srivastava, R.; Dickinson, B.C.; Janga, S.C.

BMC Genomics, 23, 172 (2022). BioRxiv

Methods for the directed evolution of biomolecular interactions.

Xie, V.C.; Styles, M.J.; Dickinson, B.C.

Trends in Biochemical Sciences, 47, 403-416 (2022).

Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.

Nguyen, L.C.; Yang, D.; Nicolaescu, V.; Best, T.J.; Gula, H.; Saxena, D; Gabbard, J.D.; Chen, S.-N.; Ohtsuki, T.; Friesen, J.B.; Drayman, N.; Mohamed, A.; Dann, C; Silva, D.; Robinson-Mailman, L.; Valdespino, A.; Stock, L.; Suárez, E.; Jones, K.A.; Azizi, S.-A.; Demarco, J.K.; Severson, W.E.; Anderson, C.D.; Millis, J.M.; Dickinson, B.C.; Tay, S.; Oakes, S.A.; Pauli, G.F.; Palmer, K.E.; The National COVID Cohort Collaborative Consortium; Meltzer, D.O.; Randall, G.; Rosner, M.R.

Science Advances, 8, eabi6110 (2022). BioRxiv

Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer's disease.

Shafik, A.M.; Zhou, H.; Lim, J.; Dickinson, B.C.; Jin, P.

Hum. Mol. Genet., 31, 1673-2680 (2022).

Phage-Assisted Continuous Evolution and Selection of Enzymes for Chemical Synthesis.

Jones, K.A.; Snodgrass, H.M.; Belsare, K.; Dickinson, B.C.*; Lewis, J.C.*

ACS Cent. Sci., 7, 1581-1590 (2021). *co-corresponding authors. ChemRxiv

Antiviral Evaluation of Hydroxyethylamine Analogs: Inhibitors of SARS-CoV-2 Main Protease (3CLpro), A Virtual Screening and Simulation Approach.

Gupta, Y.; Kumar, S.; Zak, S.E.; Jones, K.A.; Upadhyay, C.; Sharma, N.; Azizi, S.A.; Kathayat, R.S.; Poonam; Herbert, A.S.; Durvasula, R.; Dickinson, B.C.; Dye, J.M.; Rathi, B.; Kempaiah, P.

Bioorg. Med. Chem., 47, 116393 (2021).

Inhibitors of DHHC family proteins.

Lan, T.; Delalande, C.; Dickinson, B.C.

Curr. Opin. Chem. Biol., 65, 118-125 (2021).

Contingency and chance erase necessity in the experimental evolution of ancestral proteins.

Cochran Xie, V.; Pu, J.; Metzger, B.; Thornton, J.; Dickinson, B.C.

eLife, 10:e67336 (2021). BioRxiv

Development of an acrylamide-based inhibitor of protein S-acylation.

Azizi, S.-A.; Lan, T.; Delalande, C.; Kathayat, R.S.; Mejia, F.B.; Qin, A.; Brookes, N.; Sandoval, P.J.; Dickinson, B.C.

ACS Chem. Biol., 16, 1546-1556 (2021). ChemRxiv

A system for the evolution of protein-protein interaction inducers.

Dewey, J.D.; Azizi, S.-A.; Lu, V.; Dickinson, B.C.

ACS Syn. Biol., 10, 2096-2110 (2021). ChemRxiv

Programmable technologies to manipulate gene expression at the RNA level.

Liu, H.; Rauch, S.; Dickinson, B.C.

Curr. Opin. Chem. Biol., 64, 27-37 (2021).

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.

Drayman, N.; Demarco, J.K; Jones, K.A.; Azizi, S.-A.; Froggatt, H.M.; Tan, K.; Maltseva, N.I.; Chen, S.; Nicolaescu, V.; Dvorkin, S.; Furlong, K.; Kathayat, R.S.; Firpo, M.R.; Mastrodomenico, V.; Bruce, E.A.; Schmidt, M.M.; Jedrzejczak, R.; Munoz-Alia, M.A.; Schuster, B.; Nair, V.; Han, K.; O'Brien, A.; Tomatsidou, A.; Meyer, B.; Vignuzzi, M.; Missiakas, D.; Botten, J.W.; Brooke, C.B.; Lee, H.; Baker, S.C.; Mounce, B.C.; Heaton, N.S.; Severson, W.E.; Palmer, K.E.; Dickinson, B.C.; Joachimiak, A.; Randall, G.; Tay, S.

Science, 373, 931-936 (2021). BioRxiv

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.

Osipiuk, J.; Azizi, S.-A.; Dvorkin, S.; Endres, M.; Jedrzejczak, R.; Jones, K.A.; Kathayat, R.S.; Lisnyak, V.G.; Maki, S.L.; Kang, S.; Kim, Y.; Nicolaescu, V.; Taylor, C.A.; Tesar, C.; Zhang, Y.; Zhou, Z.; Randall, G.; Michalska, K.; Snyder, S.A.*; Dickinson, B.C.*; Joachimiak, A.*

Nat. Commun., 12, 743 (2021). *co-corresponding authors. BioRxiv

Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays.

Gupta, Y.; Maciorowski, D.; Zak, S.E.; Jones, K.A.; Kathayat, R.S.; Azizi, S.-A.; Mathur, R.; Pearce, C.M.; Ilc, D.J.; Husein, H.; Herbert, A.S.; Bharti, A.; Rathi, B.; Durvasula, R.; Becker, D.P.; Dickinson, B.C.; Dye, J.M.; Kempaiah, P.

Methods, 195, 57-71 (2021).

Imaging Mitochondrial Hydrogen Peroxide in Living Cells.

Lippert, A.R.; Dickinson, B.C.; New, E.J.

Methods Mol. Biol., 2275, 127-140 (2021).

Molecular synthetic biology: From understanding life to creating smart therapeutics.

Dickinson, B.C. and Shoulders, M.

Curr. Opin. Chem. Biol., 64, A1-A2 (2021).

Engineering, evolving, and designing proteins.

Aharoni, A. and Dickinson, B.C.

Curr. Opin. Struct. Biol., 69, iii-v (2021).

A stop sign for RAS trafficking.

Qiu, T. and Dickinson, B.C.

Nat. Chem. Biol., 17, 840-841 (2021).

Small molecule-inducible RNA-targeting systems for temporal control of RNA regulation.

Rauch, S.; Jones, K.; Dickinson, B.C.

ACS Cent. Sci., 6, 1987-1996 (2020). ChemRxiv

Split T7 RNA Polymerase Biosensors to Study Multiprotein Interaction Dynamics.

Dewey, J.A. and Dickinson, B.C.

Methods Enzymol., 641, 413-432 (2020).

Endothelial palmitoylation cycling coordinates vessel remodeling in peripheral artery disease.

Wei, X.; Adak, S.; Zayed, M.; Yin, L.; Feng, C.; Speck, S.L.; Kathayat, R.S.; Zhang, Q.; Dickinson, B.C.; Semenkovich, C.F.

Circ. Res., 127, 249-265 (2020).

A phage-assisted continuous selection approach for deep mutational scanning of protein-protein interactions.

Zinkus-Boltz, J.; DeValk, C.; Dickinson, B.C.

ACS Chem. Biol., 14, 2757-2767 (2019). ChemRxiv

Activity-based sensing of S-depalmitoylases: Chemical technologies and biological Discovery.

Azizi, S.-A.; Kathayat, R.S.; Dickinson, B.C.

Acc. Chem. Res., 53, 3029-3038 (2019).

Recent advances in developing and applying biosensors for synthetic biology.

Jones, K.; Zinkus-Boltz, J.; Dickinson, B.C.

Nano Futures, 3, 042002 (2019).

ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5.

Cao, Y.; Qiu, T.; Kathayat, R.; Azizi, S.-A.; Thorne, A.K.; Ahn, D.; Fukata, Y.; Fukata, M.; Rice, P.; Dickinson, B.C.

Nat. Chem. Biol., 15, 1232-1240 (2019).

Evolution of a reverse transcriptase to map N1-methyladenosine in human mRNA.

Zhou, H.; Rauch, S.; Qing, D.; Cui, X.; Zhang, Z.; Nachtergaele, S.; Sepich, C.; He, C.; Dickinson, B.C.

Nat. Methods, 16, 1281-1288 (2019).

Development of a split esterase for multimodal protein-protein interaction detection.

Jones, K.; Kentala, K.; Beck, M.W.; An, W.; Lippert, A.; Lewis, J.; Dickinson, B.C.

ACS Cent. Sci., 5, 1768-1776 (2019). ChemRxiv

Palmitoylation is required for TNF-R1 signaling.

Zingler, P.; Särchen, V.; Glatter, T.; Caning, L.; Saggau, C.; Kathayat, R.S.; Dickinson, B.C.; Adam, D.; Schneider-Brachert, W.; Schütze, S.; Fritsch, J.

Cell Commun. Signal., 17:90 (2019).

Programmable RNA-guided RNA effector proteins built from human parts.

Rauch, S.; He, E.; Srienc, M.; Zhou, H.; Zhang, Z.; Dickinson, B.C.

Cell, 178, 122-134 (2019).

Measuring S-depalmitoylation activity in vitro and in live cells using fluorescent probes.

Kathayat, R.S. and Dickinson, B.C.

Protein Lipidation: Methods and Protocols, Methods Mol. Biol., 99-109 (2019).

Evolution of C-terminal modification tolerance in full-length and split T7 RNAP biosensors.

Pu, J.; Disare, M.; Dickinson, B.C.

ChemBioChem, 20, 1547-1553 (2019).

Targeted m6A reader proteins to study the epitranscriptome.

Rauch, S. and Dickinson, B.C.

Methods Enzymol., 621, 1-16 (2019).

Expanding the chemical scope of RNA base editors.

Rauch, S. and Dickinson, B.C.

Biochemistry, 58, 3555-3556 (2019).

Targeted m6A reader proteins to study epitranscriptomic regulation of single RNAs.

Rauch, S.; He, C.; Dickinson, B.C.

J. Am. Chem. Soc., 140, 11974-11981 (2018).

Wnt5a Signaling Induced Phosphorylation Increases APT1 Activity and Promotes Melanoma Metastatic Behavior.

Sagedhi, R.S.; Kulej, K.; Kathayat, R.S.; Garcia, B.A.; Dickinson, B.C.; Brady, D.C.; Witze, E.S.

eLife, 7:e34362 (2018).

Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes.

Kathayat, R.S.; Cao, Y.; Elvira, P.; Sandoz, P.A.; Zaballa, M.-E.; Springer, M.Z.; Drake, L.E.; MacLeod, K.F.; van der Goot, F.G.; Dickinson, B.C.

Nat. Commun., 9, 334 (2018).

A fluorescent probe with improved water solubility permits the analysis of protein S-depalmitoylation activity in live cells.

Qiu, T.; Kathayat, R.S.; Cao, Y.; Beck, M.; Dickinson, B.C.

Biochemistry, 57, 221-225 (2018).

Multidimensional chemical control of Cas9 using evolved RNA polymerase-based biosensors.

Pu, J.; Kentala, K.; Dickinson, B.C.

ACS Chem. Biol., 13, 431-437 (2018).

Repurposing a viral protein and drugs that target it for synthetic biology.

Dickinson, B.C.

Nat. Methods, 15, 489-490 (2018).

Programmable RNA binding proteins for imaging and therapeutics.

Rauch, S. and Dickinson, B.C.

Biochemistry, 57, 363-364 (2018).

Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues.

Beck, M.W.; Kathayat, R.S.; Cham, C.M.; Chang, E.B.; Dickinson, B.C.

Chem. Sci., 8, 7588-7592 (2017).

RNA Polymerase tags to monitor multidimensional protein-protein interactions reveal competition between Bcl-2 proteins upon pharmacological engagement.

Pu, J.; Dewey, J.A.; Hadji, A; LaBelle, J.L.; Dickinson, B.C.

J. Am. Chem. Soc., 139, 11964-11972 (2017).

Evolution of a split RNA polymerase as a versatile biosensor platform.

Pu, J.; Zinkus-Boltz, J.; Dickinson, B.C.

Nat. Chem. Biol., 13, 432-438 (2017).

A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling.

Kathayat, R.S.; Elvira, P.; Dickinson, B.C.

Nat. Chem. Biol., 13, 150-152 (2017).

A panel of Protease-Responsive RNA Polymerases respond to biochemical signals by production of defined RNA outputs in live cells.

Pu, J.; Chronis, I.; Ahn, D.; Dickinson, B.C.

J. Am. Chem. Soc., 136, 15996-15999 (2015).

Metabolism: Plugging the leak.

Dickinson, B.C.

Nat. Chem. Biol., 11, 831-832 (2015).

Voices of Chemical Biology.

Nat. Chem. Biol., 11, 378-379 (2015).